adverse reactions of gold sodium thiomalate in rheumatoid arthri tis patients in southern iran
نویسندگان
چکیده
to confirm the side-effects of gold sodium thiomalate (gstm), we carried out a retrospective study examining 102 consecutive patients with rheumatoid arthritis attending the rheumatology unit of hafez hospital, shiraz, iran, in whom gstm was initiated between 1983-1989. only patients with classical or definite ra (ara criteria) we(e included in this study. patients were categorized as having developed toxicity to gold if rash, stomatitis, leukopenia «4000/mm3), thrombocytopenia «ioo,000/mm3), anemia (hb<10gm/dl), microscopic hematuria (more than 5 rbc in each hpf) and proteinuria (1 +or more) appeared during chrysotherapy. sixty-six (64.7%) patients developed adverse reactions. more significant side-effects were pruritus (57.8%), eosinophilia (23.5%), microscopic hematuria (20.5%), and low hb (20.5%). inadequate primary response and relapses on therapy accounted for termination in 15.6% of patients, nephrotic syndrome in 0.9%, hepatitis in 1.9%, colitis in 2.9%, persistent pruritus in 1.9%, extensive lichenoid rash in 3.9%, persistent stomal ulcer in 0.9% and persistent hematuria in 1.9% of patients. lichenoid rash was more significant and more extensive in our series compared to others.
منابع مشابه
ADVERSE REACTIONS OF GOLD SODIUM THIOMALATE IN RHEUMATOID ARTHRI TIS PATIENTS IN SOUTHERN IRAN
To confirm the side-effects of gold sodium thiomalate (GSTM), we carried out a retrospective study examining 102 consecutive patients with rheumatoid arthritis attending the Rheumatology Unit of Hafez Hospital, Shiraz, Iran, in whom GSTM was initiated between 1983-1989. Only patients with classical or definite RA (ARA criteria) we(e included in this study. Patients were categorized as havi...
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عنوان ژورنال:
medical journal of islamic republic of iranجلد ۹، شماره ۳، صفحات ۱۸۹-۱۹۲
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